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Computational approaches in design of nucleic acid-based therapeutics

Eslicarbazepine: Higher affinity for the inactive state of the voltage-sensitive sodium channel (causing greater inhibitory effect on rapidly firing neurons

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FOXO4-DRI eliminated fibroblasts in G0/G1 phase cell cycle arrest and selectively induced senescent keloid cells apoptosis in an in vitro model of fibroblasts and organ culture In the serum limitation-induced senescent fibroblast model, more SA--gal-positive cells were observed in keloid fibroblasts compared with that in normal skin fibroblasts (Fig