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SE=standard error * Statistically significant versus placebo based on the pre-specified method for controlling Type I error across multiple doses Study 2 adjusted for baseline bodyweight and diabetic status Among the 388 subjects with type 2 diabetes mellitus treated in Study 2, reductions in HbA1c from baseline (6.8%) were 0.1% for placebo compared to 0.4% and 0.4% with phentermine and topiramate extended-release 7.5 mg/46 mg and phentermine and topiramate extended-release 15 mg/92 mg, respectively

The Journal of biological chemistry , 289 (28), 1950819518