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The established urinary threshold level of 150 g/mL may be reached (rarely, but possibly) in some individuals within 6-20 hours of taking some long-acting therapeutic formulations
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However, one study on the treatment of children with methylmalonic acidemia and homocystinuria found oral hydroxocobalamine at 1 mg daily to be ineffective in reducing levels of homocysteine
SIPS is a phenomenon characterized by the irreversible cessation of the division of normal cells even in presence of nutritional and mitogenic factors 27
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