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GLP-1 peptides are large, hydrophilic (water-loving), and charged
doi: 10.1007/s12155-022-10537-8 124
However, limitations remain, including dose-escalationrelated GI intolerance, insufficient long-term safety, and currently unestablished relative potency compared with injectable GLP-1 RAs and multi-receptor peptide agonists [76]
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