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To document the severity and extension, a semi-quantitative grading system was used based on previously used histological criteria: Gastric and colon mucosa inflammatory cell infiltrate and multifocal areas of crypt (large intestine) or glandular (stomach) epithelial cell dysplasia were scored from 0 to 5, where 0 indicates absence of lesion and 5 indicates very intense lesions
Among these categories, increased beta-3-adrenergic-receptor RNA expression was directly reported in the cited AOD9604 mouse study
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