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To overcome these obstacles, new strategies for oral delivery of biomacromolecules have been developed, such as the use of permeation enhancers (PEs), protease inhibitors and nanoparticle-based delivery systems [6,7]

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Liver Dose Adjustments Data not available Dialysis Hemodialysis: See Usual Adult or Pediatric dosing Peritoneal dialysis: Data not available Other Comments Administration advice: Oral solutions may be consumed alone, or dissolved in other drinks or liquid foods to reduce taste fatigue