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Supplementation will particularly help vegans and vegetarians increase muscle concentrations of carnitine and shuttle fatty acids to be used for energy

Excess long-chain acylcarnitines and ceramides disrupt sarcolemmal integrity, trigger arrhythmogenic signaling, and exacerbate contractile dysfunction

The available data remain largely preclinical or based on limited observations, and its non-selectivity is also its main limitation: by affecting multiple receptors, it is associated with varied effects reported in the literature

Key Highlights: Mechanism: Activated in the acidic canaliculi of parietal cells irreversible inhibition of the proton pump