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The clinical relevance of APAP toxicity makes understanding mechanisms of cell death induced by this drug critical for the identification of therapeutic targets and discovery of antidotes
Patients should be encouraged to prioritize nutrient-dense foods and ensure adequate protein intake (typically 1.2-1.6 g/kg of ideal body weight daily during active weight loss, with higher amounts for those engaging in resistance training)
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La Asociacin Americana de Diabetes (ADA) recomienda un enfoque centrado en el paciente para la seleccin de tratamientos, y en personas con enfermedad cardiovascular aterosclertica, alto riesgo cardiovascular, enfermedad renal crnica o insuficiencia cardaca, un GLP-1 con beneficio cardiovascular demostrado puede considerarse independientemente del uso de metformina
