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Clinical biomarker studies have produced heterogeneous associations between circulating irisin levels and indices of metabolic health, exercise capacity, and bone density across different populations, with effect sizes and directions varying by sex, age, and comorbidity status (Perakakis et al., 2017)
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Interestingly, the loss of FOXP1 and FOXP4 in the epithelium of patients with a non-Th2 asthma phenotype induces ectopic NPY production and other proteins associated with airway remodeling, such as MUC5AC
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