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Additionally, it is important to note that NR readily degrades in human and rodent plasma, and NMN degrades in human plasma, suggesting low systemic stability of the molecules when administered orally 68,124,125

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"MOTS-c can significantly enhance physical performance in young, middle-age, and old mice." Reynolds et al., Nature Communications , 2021 [3] The ceiling on all of this is the same ceiling every mitochondrial peptide hits: the outcome data is rodent data