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Internal Medicine Review 3 (2017): Issue 4

MT-1 is produced via solid-phase peptide synthesis (SPPS), a precisely controlled chemical method that ensures accurate replication of the 13-amino acid sequence while preserving the two critical structural modifications

That's why past studies have linked melanotan 2 to other effects such as heightened libido and decreased body fat levels in test subjects

A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007