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In all original studies, ethical approval and consent to participate had been obtained

The first developed metformin prodrug, namely its cyclohexyl sulfenamide derivative, was in part activated on the apical side of the enterocytes with consequent decrease of absorbtion 121

These side effects usually diminish as the body adjusts to the medication

Day 0 (the day prednisone is prescribed): Continue Zepbound on the regular weekly schedule Get a baseline finger-stick glucose if you have a meter, or note your continuous glucose monitor (CGM) reading Plan to monitor glucose 2 to 4 times daily during the steroid course Have a Tums or Pepcid plan in case reflux flares Days 1-5 (the steroid course): Take prednisone in the morning with food, as prescribed Continue Zepbound on schedule Check fasting glucose first thing in the morning Check post-meal glucose 2 hours after lunch and dinner Hydrate well (steroids increase thirst