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Additionally, co-administration of LC with TRZ significantly increased total thiol content and catalase activity while reducing malondialdehyde (MDA) levels relative to TRZ alone (Khedr et al
While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3
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