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[33] broadened the scope to 26 studies ( n = 3,020), including both metabolic RCTs with secondary psychiatric outcomes and a small number of trials in clinical populations (e.g., substance use disorders)
The HDAC inhibitor SAHA can induce the conversion of T cells into functional Tregs and alleviate pulmonary hypertension, confirming the central role of metabolic-epigenetic crosstalk in regulating T cell function ( In PH, the metabolic reprogramming of PASMCs and PAECs actively shapes the immune microenvironment through the release of specific metabolites
Researchers explore its potential role in metabolic function, insulin signaling, and weight regulation under controlled lab conditions
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