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Injection sites Thigh, abdomen (at least 2 inches from navel), or upper arm

Some researchers notice small nodules under the skin at injection sites

When to contact your healthcare provider: Severe or persistent nausea and vomiting that prevents adequate oral intake Signs of dehydration (decreased urination, dizziness, dry mouth) Severe abdominal pain, especially if persistent or radiating to the back Symptoms of hypoglycemia if taking tirzepatide with insulin or sulfonylureas (shakiness, sweating, confusion, rapid heartbeat) Unusual injection site reactions (severe pain, swelling, redness) Intractable vomiting or inability to keep fluids down Any other concerning symptoms For future injections: Review proper injection technique with your healthcare provider or a diabetes educator before your next dose

This has led some experts to recommend taking glutathione supplements in the morning to help replenish levels