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1 At 104 weeks , the reported mean body-weight changes were: 4 mg to maximum tolerated dose: -27.9% 9 mg to maximum tolerated dose: -29.5% 12 mg to maximum tolerated dose: -30.3% placebo to retatrutide maximum tolerated dose: -19.2% 1 The 12 mg extension group lost an average of 85.0 lbs
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The most reliable predictor is the rate of weight loss, not the total amount
International Journal of Eating Disorders, 44(6), 515-523
The third arm is what sets retatrutide apart from every approved incretin drug: glucagon-receptor agonism
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