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The outer layer of the skin, Stratum Corneum, is around 1020 m (very thin), but it is the main barrier for drug penetration
doi: 10.1080/17425255.2023.2223959 [PubMed] 37552484 Dart RC, Mullins ME, Matoushek T, Ruha AM, Burns MM, Simone K, Beuhler MC, Heard KJ, Mazer-Amirshahi M, Stork CM, Varney SM, Funk AR, Cantrell LF, Cole JB, Banner W, Stolbach AI, Hendrickson RG, Lucyk SN, Sivilotti MLA, Su MK, Nelson LS, Rumack BH
So, if there are more options that can be potentially cost-effective, that would benefit more people.
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