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Connexins enable direct intercellular communication of metabolites, nucleotides, nutrients, and secondary messengers, regulating apoptosis, inflammation, and cellular growth, while also amplifying liver inflammation and cell death (Maes and Vinken 2017
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Thats why scientists are investigating how these drugs might: Reduce cravings for drugs and alcohol Curb compulsive behaviors like gambling, overeating or excessive shopping Improve mood and emotional regulation Blunt dopamine spikes associated with addictive behaviors In animal studies, GLP-1 medications have shown promise in reducing self-administration of addictive substances like cocaine, alcohol and nicotine
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