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The severity of these symptoms is mainly mild to moderate, and they are most prominent at treatment initiation and intensification (44)

Future studies could investigate the synergistic effects of combining this oral GLP-1 agonist with other diabetes medications, potentially leading to more effective multi-drug regimens

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SLC19A1, a gene encoding a membrane folate carrier, was reduced in obese WAT and induced global DNA hypermethylation of chemokine C-C motif chemokine ligand 2 (CCL2) that is a key factor in WAT inflammation, 219 resulting in increased CCL2 protein secretion and the development of IR in obese