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Additionally, adequate protein can help prevent excessive bone density loss during weight loss, which is another concern for some individuals
Cechin S, Perez-Alvarez I, Fenjves E, et al
Phosphodiesterase-5 (PDE5) inhibitors such as sildenafil are often effective first-line treatments and are generally safe to use alongside GLP-1 medications, though they are contraindicated with nitrate medications and riociguat, and should be used with caution in unstable cardiovascular disease or if taking alpha-blockers
77 A Cochrane review of the use of NAC in children with respiratory infections evaluated the safety data from 34 clinical trials, involving 2064 children, and found NAC to be safe, although the authors note that 59 cases of paradoxically increased bronchorrhoea (increased sputum production) in infants under the age of 2 years were reported to the French pharmacovigilance system
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