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In the pancreas, they stimulate glucose-dependent insulin secretion, meaning insulin is released only when blood glucose levels are elevated, thereby reducing hypoglycaemia risk
Diabetic ketoacidosis (DKA) : Whilst uncommon with GLP-1 agonists, cases have been reported, particularly if insulin doses are rapidly reduced or stopped
How GLP-1 Medications Work GLP-1 medications mimic the action of a natural hormone called glucagon-like peptide-1 , which plays a critical role in regulating: Appetite and Satiety : GLP-1 slows down stomach emptying and signals the brain to reduce hunger
Future Directions Tirzepatide represents just the beginning of multi-agonist approaches
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