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The GLP-2 receptor is 14 exons long and has seven transmembrane domains and, although similar in amino acid sequence to both the glucagon and GLP-1 receptor, only recognizes GLP-2 and not related members of the glucagon family ( GLP-2R is expressed in the gastric mucosa in a subpopulation of fundas gland cells (Li et al., 2017) (Table 3)
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Because SNAC protects semaglutide from pH-dependent degradation and the consumption of food leads to an increase in gastric pH, the effect of food and water on systemic semaglutide exposure was investigated
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