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Sepsis: A small RCT in patients with sepsis found that IV NAC (150 mg/kg bolus then 50 mg/kg over 4 hours) improved hepatosplanchnic perfusion, glutathione levels, and liver function markers
Its also possible for the combination to bring about side effects that are less common when the drugs are taken separately, given the interaction between the medications mechanisms of action
Experimental investigations have reported changes in antioxidant enzyme activity and oxidative markers following Epithalon exposure in controlled environments
However, another randomized, double-blind, placebo-controlled trial in 181 patients with diabetic neuropathy found that oral supplementation with either 600 mg/day, 1,200 mg/day, or 1,800 mg/day of lipoic acid for five weeks significantly improved neuropathic symptoms (77)
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