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Seek immediate medical attention for severe, persistent abdominal pain radiating to the back Gallbladder disease : Rapid weight loss can increase gallstone risk Hypoglycaemia : Particularly when combined with insulin or sulfonylureas Diabetic retinopathy complications : Rapid glucose improvement may temporarily worsen retinopathy in susceptible patients Animal studies showed thyroid C-cell tumours with semaglutide, though the relevance to humans is unknown

During mastication they are enzimatically converted into thiocyanates, goitrin metabolites, that cause a competitive inhibition of the sodium/iodide symporter, thus inhibiting the thyroid hormones synthesis and possibly causing hypothyroidism [156]

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