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In vitro studies have demonstrated that hypoxia-induced endometrial stromal cell senescence leads to impaired decidualization as evidenced by incomplete morphological transformation and reduced expression of decidualization markers IGFBP1 and PRL ( in vitro decidualization of HESCs, confirmed by upregulated expression of PRL , IGFBP1 and FOXO1 , resulted in an increase in expression of senescence markers p21 and p53 , suggesting that decidualization may promote cellular senescence (Kusama et al., 2021)

Using United States Department of Veterans Affairs databases, an analysis of 175 health outcomes in 215,970 individuals using GLP1-RAs as usual care for type 2 diabetes was compared to individual cohorts who used other common diabetes treatments, such as sulphonylureas, dipeptidyl peptidase-4 inhibitors, and sodium-glucose cotransporter-2 inhibitors

Brightening: This generally refers to improving radiance and tonereducing dullness and evening out the complexion rather than changing your natural skin shade