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10.1016/0014-5793(78)80779-0 106 HalliwellB
We have shown that CuCl 2 and Cu(OAc) 2 irritation induces the upregulation of various genes without the concomitant inhibition of cell viability
This neuronal gene activation correlates with observed anti-pain, anti-anxiety, and cognitive enhancement effects in animal studies at doses as low as 0.5 g/kg body weight
A 2009 review article about the safety of nanoparticles summarizes this, "to date, in-vivo and in-vitro studies have not demonstrated percutaneous penetration of nanosized particles in titanium dioxide and zinc oxide sunscreens"
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