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Taken together, these findings suggest that Nrf2 plays a vital role in mediating the chondroprotective effects of metformin by means of anti-oxidation, and that loss of Nrf2 substantially attenuates, but does not completely abolish, the therapeutic efficacy of metformin in the MIA-induced OA model

However, because this product provides doses far above the daily nutritional requirements (for instance 100 mg of B vs an RDA of ~1.4 mg), its use in pregnancy must be carefully considered

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Chronic Conditions That Respond Well Certain chronic conditions appear particularly suited to the micro-dosing approach