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In male rats, a HFD (G0-P21) reduced POS-induced cognitive impairments as measured in the MWM at M4-7 [137] and the conditioned odor preference (COP) at M6 [141]

GLP-1s work on gut hormones and slow digestion, producing the highest average weight loss of any current option, often 15 to 20 percent or more of body weight

Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype

These agents preferentially lower fasting and postprandial hyperglycemia according to their pharmacokinetic (PK) characteristics, while also being associated with body weight loss [1,2,3,4,5,6]