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Large-scale human clinical trials have not yet been completed
This is unusual for peptides
Semaglutides trade-offs are cost, gastrointestinal side effects, contraindications including medullary thyroid carcinoma history, and the need for careful titration
It remains under investigation in clinical trials registered on ClinicalTrials.gov and the EU Clinical Trials Register, and is not licensed for prescription or self-administration outside of formally approved research settings
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