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27 However, hepatic lipase deficiency in lecithin:cholesterol acyltransferase (LCAT)Tg and apoEKO mice significantly reduced aortic atherosclerosis despite the increase in cholesterol content in the apoB-containing lipoproteins

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Both of these responses can be produced by exposing cells to hydrogen peroxide, and inhibited by increasing GPX1 activity, either by overexpression or via the addition of sodium selenite to cell culture media (17, 18)

For example, the BNF notes that pancreatin can reduce the effect of acarbose (an antidiabetic medication) [13] [14] Allergic reactions : Many products are derived from animal (often porcine) or fungal sources and may trigger sensitivities or have religious implications Gastrointestinal irritation : High-dose enzyme supplements may worsen nausea or abdominal discomfort in some individuals Masking underlying conditions : Self-treating with supplements may delay diagnosis of serious digestive disorders Before purchasing any supplement, check the ingredient list carefully for allergens and avoid products making exaggerated health claims