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Dose escalation, which is standard practice with most GLP-1 medications, helps to optimise therapeutic effects whilst minimising gastrointestinal side effects

For example, a combination of NAC (1200 mg/day) and L-arginine (1600 mg/day) for 6 months to treat 8 oligo-menorrhoeic patients with PCOS helped restoring the menstrual function, as evidenced by the increased number of menstrual cycles, and significantly decreased the homeostatic model assessment (HOMA) index (144)

One study showed that people who took Wellbutrin alongside diet and exercise changes were able to lose 10% of their body weight after 24 weeks

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