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doi:10.1002/oby.20154 Mao T, Huang F, Zhu X, Wei D, Chen L

Another breakthrough in obesity medication acceptance was the SELECT trial [7], the first cardiovascular outcome trial in persons with overweight and obesity with established cardiovascular disease (prior myocardial infarction, stroke or symptomatic peripheral artery disease) to show reduction in major adverse cardiovascular events (MACE) [7]

However, much of it is lost to stomach acid and enzymes on the way through the digestive tract

Quick Summary: Semaglutides weight loss over 3 months varies by dose and individual factors but many adults in clinical trials lose significant weight (often mid-teens percentage of baseline body weight) with adherence to dosing and supportive lifestyle changes