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It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications

After 4 weeks at therapeutic doses, most users report 50-70% reduction in pain, significantly improved function, and ability to resume modified training or activities

It only calculates concentration and volume relationships