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IRF1 drives the expression of the transferrin receptor, promotes intracellular Fe2+ accumulation, disrupts iron homeostasis, and induces ferroptosis in cancer cells, while blocking Gln enhances this effect ( in vivo , and decrease tumor development in xenograft mouse models
SARS-CoV-2 spike glycoprotein binds TLR4 and activates TLR4 signaling increasing cell surface expression of ACE2 facilitating entry (Aboudounya and Heads, 2021)
2.Uberti, F., Morsanuto, V., Ruga, S., Galla, R., Farghali, M., Notte, F., Bozzo, C., Magnani, C., Nardone, A., & Molinari, C
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