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FDA identified possible immunogenicity risks from aggregation and peptide-related impurities and proposed not adding either defined TB-500 substance to the 503A Bulks List

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Further structural analysis via the program AlphaFold 46 was conducted to visualize and better comprehend the interactions of the exendin 2029 sequence with TRPV1 within the broader context of GLP-1 and its derivatives (Supplementary Fig

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