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Its stability depends on the metal staying coordinated to the tripeptide, which makes it sensitive to pH, since the deprotonated amide nitrogen that helps hold the copper is pH-dependent, and outright incompatible with two whole classes of common additive

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JNK, a stress-activated protein kinase and a member of the mitogen-activated protein kinase (MAPK) family, has significant roles in the apoptotic process and airway remodeling in asthma by inducing the Wnt5a/JNK signaling pathway