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The resultant files were processed with El-Maven (Elucidata) alongside the Kyoto Encyclopedia of Genes and Genomes (KEGG) 20,21,22 database for metabolite assignment and manual peak integration as previously described using intact mass, isotopic patterns, and an in-house standard library 23

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While preclinical models demonstrate developmentally-regulated windows of pulmonary susceptibility to paracetamol exposure, 10 if and how these findings translate clinically is unknown