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10.1016/j.jff.2016.03.028 23 ChenY

In RSL3-induced glioblastoma cell models, excessive activation of NF-KB represses ATF4 and SLC7A11, causing overproduction of lipid peroxidation byproducts and exacerbating ferroptosis (126)

While it is important to note that most evidence remains preclinical, the breadth and consistency of findings across different research models provides a strong foundation for understanding the compound therapeutic potential