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The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation: Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies
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Under normal conditions, the metabolic substrate is primarily fatty acid oxidation
Nuclear PIP 2 (PtdIns-4,5-P 2 ) is involved in the regulation of RNA polymerase I-mediated transcription of ribosomal RNA, the regulation of the poly(A)-polymerase involved in the transcription of stress-related mRNAs, and the targeting of proteins to splicing complexes that are involved in the export of spliced mRNAs to the cytosol
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