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Treatment with thyroid hormone

Cardiovascular safety outcome trials included patients with T2DM and either established CV disease or multiple CV risk factors (and albuminuria or impaired renal function in CARMELINA)

Under the regulation of AMPK in the ventral medial hypothalamus, they could promote the conversion of visceral white adipose tissue (WAT) to brown adipose tissue (BAT), promoting thermogenesis of BAT and thus energy consumption (182)