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Jumping back in at a maintenance dose after a long break can cause severe nausea and vomiting

The adverse reactions, reported regardless of investigator assessment of causality in 5% of patients treated with Januvia 100 mg daily as monotherapy, Januvia in combination with pioglitazone, or Januvia in combination with glimepiride, with or without metformin, and more commonly than in patients treated with placebo, are shown in Table 1

As the intricate interplay between carbohydrate metabolism, the Warburg effect, and cancer progression garners increasing attention, attaining a comprehensive understanding of the roles played by DPP-IV and SGLT2 inhibitors in PTC management may serve as the cornerstone for novel approaches aimed at enhancing patient care and broadening the spectrum of available therapeutic modalities

[10] This supports a role for an NPY-related pathway in that animal model