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In cardiovascular disease , studies have found these medications provide cardiovascular protection, with a 1420% reduction in major adverse cardiovascular events (MACE), a benefit understood to be at least partially mediated by anti-inflammatory pathways rather than glycemic control alone

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Patients with type 2 diabetes usually have co-morbid obesity, and our data validated that various GLP-1RA drugs had weight loss effects, especially CagriSema, tirzepatide, and retatrutide, thus enriching the clinical therapeutic approaches