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SURMOUNT-1 (N=2,539) demonstrated 20.9% mean body weight reduction at 72 weeks with tirzepatide 15 mg versus 3.1% with placebo

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Importantly, the fusion proteins that remained bound to the immobilized receptor at the end of the dissociation phase, rapidly dissociated upon injection of a pH 7.4 buffer during the regeneration phase (Supplementary Fig

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