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39,43 In contrast, among HFpEF cohorts, semaglutide showed clinically meaningful benefits in non-diabetic and diabetic cohorts ( Table 1 )

What is more, no clear trend for a change in pharmacokinetics was evident across groups with increasing renal dysfunction 12 that allowed us to administer the same dose of the drug and the same blood sampling time points in patients with different degree of renal impairment who were included in our study