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Furthermore, we identified the sources of the metabolites and found 23 metabolites from the host, 85 metabolites from the microbiota, 198 metabolites from host-microbiota cometabolism, and 876 metabolites from others, which consisted of drug (128), food (348), environment (9), and unknown (391) (Fig

Compared to cognitively normal older adults, cerebrovascular resistance is higher in individuals with MCI and ADRD, and has been associated with greater A burden, cortical atrophy, and risk of progression to ADRD (Yew and Nation, 2017)