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The main mechanisms include: Paternal deletion of the region (most common) Maternal uniparental disomy (UPD) both chromosome copies come from the mother Imprinting defects causing improper gene expression These genetic disruptions lead to abnormal development of the hypothalamus, affecting hunger, hormone regulation, and behavior

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Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food. Diabetes, vol