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These aren't trivial changes

Chemico-Biol Interact (2015) 233:2534

Indar AA, Beckingham IJ

We found that glutathione and thioredoxin, the major thiol antioxidants, and glutathione and thioredoxin reductases, the enzymes responsible for maintaining them in a reduced state, fell substantially in rodent bone marrow after ovariectomy and were rapidly normalized by exogenous 17- estradiol