mechanism of semaglutide as a Cornerstone Therapy in Obesity: Clinical and Pharmacological Insights How Does Semaglutide Work to

Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, et al

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Ascletis states it plans to submit an FDA IND in Q2 2026 for obesity

The $50 billion investment across our R&D and manufacturing footprint in the US over the next five years also includes: Expansion of our R&D facility in Gaithersburg, Maryland State-of-the-art R&D center in Kendall Square, Cambridge, Massachusetts Next-generation manufacturing facilities for cell therapy in Rockville, Maryland and Tarzana, California Continuous manufacturing expansion in Mount Vernon, Indiana Specialty manufacturing expansion in Coppell, Texas New sites to supply clinical trials Our growing research and development investment in novel medicines Collectively, these investments will help deliver AstraZenecas ambition of reaching $80 billion in Total Revenue by 2030, of which we expect 50% would be generated in the US