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Primary care physicians will likely need education and training focused on this new class of medications, given a shortage of endocrinologists and obesity medicine specialists. Lee and colleagues noted there were study limitations, such as a lack of data on prescription indication, including whether it was used off-label. However, the increase in dispensing of injectable semaglutide for weight management suggests increasing use for this indication, they wrote

Based on early-stage development information: While regulatory approval and large clinical trials will determine its final role in treatment, investigational oral GLP-1 medicines like ZYOG1 represent the next phase in metabolic therapy

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