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AMPK is central to energy regulation, lipid oxidation, and inflammation control ( Spirulina platensis and its phycocyanin content can activate AMPK pathways, improving lipid metabolism and redox balance ( The therapeutic effects of Spirulina have been attributed to its rich content of bioactive metabolites, including phycocyanin, -carotene, and phenolic acids, which exhibit strong antioxidant, anti-inflammatory, and lipid-lowering properties (Khan et al., 2005)

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In the REDEFINE 1 phase 3 trial (NCT05567796), which enrolled adults with overweight or obesity (BMI 27 kg/m) and at least 1 weight-related comorbidity but without type 2 diabetes, participants receiving CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) achieved a mean body weight reduction of 22.7% from baseline after 68 weeks among adherent participants, compared with approximately 3% in the placebo group

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The injection works by acting on the GLP-1 receptors, which results in decreased appetite and improved satiety

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